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Synthesis of Heterocyclic-Substituted Chromones and Related Compounds as Potential Anticancer Agents1

D Donnelly, R Geoghegan, C O'Brien…

文献索引:Donnelly,D. et al. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 872 - 875

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被引用次数: 19

摘要

Of chief interest among the compounds tested for anticancer activity in the earlier seriesJ3 and so far in the present one, is 6-chloro-2-(2-quinolyl) chromone (XV). This displayed borderline, though significant, activity against Sarcoma 180 in all trials. KO comparable degree of activity was shown by the other 2-(2-quinolyl) chromones (XI11 and XIV) and this finding tempted us to correlate the activity of the compound with the presence of the ...