The influence of substitution at aromatic part of 1, 2, 3, 4-tetrahydroisoquinoline on in vitro and in vivo 5-HT 1A/5-HT 2A receptor activities of its 1- …

…, A Kłodzińska, E Chojnacka-Wójcik

文献索引：Bojarski, Andrzej J; Mokrosz, Maria J; Minol, Sijka Charakchieva; Koziol, Aneta; Wesolowska, Anna; Tatarczynska, Ewa; Klodzinska, Aleksandra; Chojnacka-Wojcik, Ewa Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 1 p. 87 - 95

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被引用次数: 20

摘要

Further structure–activity relationship (SAR) studies with the 1, 2, 3, 4-tetrahydroisoquinoline (THIQ) class of 5-HT1A ligands led to the synthesis of new 1-adamantoyloaminoalkyl derivatives. The impact of substituent variations in the aromatic part of THIQ moiety on 5- HT1A and 5-HT2A receptor affinities, as well as in vivo functional properties of the investigated compounds were discussed. It was found that those modifications reduced ...