A novel synthesis of nucleoside 5′-triphosphates

NC Mishra, AD Broom

文献索引：Mishra, Nrusingha C.; Broom, Arthur D. Journal of the Chemical Society, Chemical Communications, 1991 , # 18 p. 1276 - 1277

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被引用次数: 30

摘要

Facile syntheses of ribonucleoside 5′-triphosphates have been accomplished in good yield (> 60%) in a one-pot reaction of unprotected nucleosides with phosphoryl chloride followed by treatment of the resulting phosphorodichloridate with tri-n-butylammonium phosphate in the presence of dimethylformamide.