Carbocyclic analogs of 5-substituted uracil nucleosides. Synthesis and antiviral activity

YF Shealy, CA O'Dell, WM Shannon…

文献索引：Shealy; O'Dell; Shannon; Arnett Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 156 - 161

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被引用次数: 58

摘要

Carbocyclic analogues of 3'-deoxyuridines, 3'-deoxyuridines, and uridines with substituenb at position 5 of the uracil moiety were prepared by direct halogenation (5-bromo and B-iOdO groups) and by displacement of the 5-bromo group by amino and substituted-amino groups. The analogue of 5-(hydroxymethy1) uridine was prepared via reaction of the isopropylidene derivative of the uridine analogue with paraformaldehyde. The carbocyclic analogues of ...