Identification of 2-amino-5-(thioaryl) thiazoles as inhibitors of nerve growth factor receptor TrkA

…, BE Fink, ME Salvati, R Moquin, MT Obermeier…

文献索引：Kim, Soong-Hoon; Tokarski, John S.; Leavitt, Kenneth J.; Fink, Brian E.; Salvati, Mark E.; Moquin, Robert; Obermeier, Mary T.; Trainor, George L.; Vite, Gregory G.; Stadnick, Linda K.; Lippy, Jonathan S.; You, Dan; Lorenzi, Matthew V.; Chen, Ping Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 634 - 639

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被引用次数: 17

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... 2-Amino-5-(thioaryl)thiazoles are potent inhibitors of TrkA (eg, 20h, TrkA IC 50 = 0.6 nM) that show anti-proliferative effect in cellular assays. A proposed inhibitor binding mode to TrkA active site is consistent with key SAR observations. ... 2-Amino-5-(thioaryl)thiazaoles are potent ...