Suzuki–Miyaura cross-coupling reactions of halo derivatives of 4 H-pyrido [1, 2-a] pyrimidin-4-ones

A Molnár, A Kapros, L Párkányi, Z Mucsi…

文献索引：Molnar, Annamaria; Kapros, Anita; Parkanyi, Laszlo; Mucsi, Zoltan; Vlad, Gabor; Hermecz, Istvan Organic and Biomolecular Chemistry, 2011 , vol. 9, # 19 p. 6559 - 6565

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被引用次数: 7

摘要

The palladium-catalyzed Suzuki–Miyaura cross-coupling reactions of halo derivatives of 4H- pyrido [1, 2-a] pyrimidin-4-one with (het) arylboronic acids allow easy access to (het) aryl and vinyl derivatives of this bicycle in good to excellent yields, even from chloro derivatives. The sequence of reactivity of the halogen in the different positions of the ring system was also investigated. 6-Phenyl-4H-pyrido [1, 2-a] pyrimidin-4-one could be prepared by ...