2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents

DL Klayman, JF Bartosevich, TS Griffin…

文献索引：Klayman; Bartosevich; Griffin; Mason; Scovill Journal of Medicinal Chemistry, 1979 , vol. 22, # 7 p. 855 - 862

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被引用次数: 406

摘要

Based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3- thiosemicarbazone (l), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety also contribute to antimalarial ...