Convenient synthesis of 3??methyl??1??(4??pyridinyl)??2??butanone using phenyllithium as a metalating agent

P Léon, C Garbay??Jaureguiberry…

文献索引：Leon, P.; Garbay-Jaureguiberry, C.; Roques, B. P. Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1547 - 1550

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摘要

Abstract 3-Methyl-1-(4-pyridinyl)-2-butanone has been synthesized via a short and convenient method based upon acylation of 4-picoline by phenyllithium followed by reaction with ethyl isobutyrate. This procedure can be extended to the preparation of various alkyl pyridyl ketones, intermediates in the synthesis of potential anti-tumor 6-substituted 7H- pyridocarbazole dimers.