Design, synthesis, and structure–activity relationships of pyrazolo [3, 4-d] pyrimidines: a novel class of potent enterovirus inhibitors

…, CL Tai, CC Lee, YC Lee, CS Chang, SN Tseng…

文献索引：Chern, Jyh-Haur; Shia, Kak-Shan; Hsu, Tsu-An; Tai, Chia-Liang; Lee, Chung-Chi; Lee, Yen-Chun; Chang, Chih-Shiang; Tseng, Sung-Nien; Shih, Shin-Ru Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2519 - 2525

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被引用次数: 96

摘要

A series of pyrazolo [3, 4-d] pyrimidines were synthesized and their antiviral activity was evaluated in a plaque reduction assay. It is very interesting that this class of compounds provide remarkable evidence that they are very specific for human enteroviruses, in particular, coxsackieviruses. Some derivatives proved to be highly effective in inhibiting enterovirus replication at nanomolar concentrations. SAR studies revealed that the phenyl ...