Tetrahedron Letters

A facile and efficient Bi (III) catalyzed synthesis of 1, 1-dihydroperoxides and 1, 2, 4, 5-tetraoxanes

KV Sashidhara, SR Avula, LR Singh, GR Palnati

文献索引：Sashidhara, Koneni V.; Avula, Srinivasa Rao; Ravithej Singh; Palnati, Gopala Reddy Tetrahedron Letters, 2012 , vol. 53, # 36 p. 4880 - 4884

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被引用次数: 22

摘要

The discovery of artemisinin as the active principle of the Chinese traditional drug Artemisia annua is a major step forward in malaria chemotherapy. However, because of a limited availability (natural plant sources), 1 high cost, 2 and poor bioavailability, 3 there is still a need for simple and efficient anti-malarial therapeutics. Structure activity relationship studies conducted on artemisinin and its semi-synthetic derivatives revealed that peroxide linkage is the most crucial ...