Abstract Although alkoxypyrimidines can be aminated to yield aminopyrimidines, monoamination of 2, 4-or 4, 6-chloroalkoxypyrimidines results in chlorine displacement. Preferential alkoxy displacement in such systems is unusual. We now have evidence of such a displacement in the dihydrofurano [2, 3-d] pyrimidines (V). In some cases two types of products, formed by displacement of either the chlorine or alkoxy substituent, were ...