Tetrahedron letters

Synthesis of chiral α-amino acids

TK Chakraborty, A Ghosh

文献索引：Chakraborty, Tushar K.; Ghosh, Animesh Tetrahedron Letters, 2002 , vol. 43, # 52 p. 9691 - 9693

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被引用次数: 7

摘要

A novel method for the synthesis of chiral α-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the α-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction.