A novel immunostimulator, N 2-[α-O-Benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl]-N 6-trans-(m-nitrocinnamoyl)-L-lysine, and its adjuvancy on the hepatitis B …

…, JY Bai, C Jiang, J Ding, GF Cheng, G Liu

文献索引：Yang, Hong-Zhen; Xu, Song; Liao, Xue-Yan; Zhang, Suo-De; Liang, Zheng-Lun; Liu, Bai-He; Bai, Jin-Ye; Jiang, Chao; Ding, Jian; Cheng, Gui-Fang; Liu, Gang Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5112 - 5122

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被引用次数: 13

摘要

N 2-[α-O-Benzyl-N-(acetylmuramyl)-l-alanyl-d-isoglutaminyl]-N 6-tran s-(m-nitrocinnamoyl)-l- lysine (muramyl dipeptide C, or MDP-C) has been synthesized as a novel, nonspecific immunomodulator. The present study shows that MDP-C induces strong cytolytic activity by macrophages on P388 leukemia cells and cytotoxic activity by cytotoxic T lymphocytes (CTLs) on P815 mastocytoma cells. Our results also indicate that MDP-C is an effective ...