Synthetic aci-reductones. 3, 4-Dihydroxy-2H-1-benzopyran-2-ones and their cis-and trans-4a, 5, 6, 7, 8, 8a-hexahydro diastereomers. Antiaggregatory, antilipidemic, …

…, AK Tehim, KD Sternitzke, RL McCreery…

文献索引：Witiak, Donald T.; Kim, Sung K.; Tehim, Ashok K.; Sternitzke, Kent D.; McCreery, Richard L.; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1437 - 1445

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被引用次数: 19

摘要

Synthetic procedures for the elaboration of aci-reductones belonging to the 6-or 7-mOnO-or bis-substituted-3, 4-dihydroxy-2H-l-benzopyran-2-ones (6-10) and their cis-and trans-4a, 5, 6, 7, 8, 8a-hexahydro diastereomers (11, 12) are described. Hexahydrobenzopyranone aci- reductones were conveniently prepared by using Meldrum's synthon (2, 2-dimethyl-1, 3- dioxane-4, 6-dione, 49). Certain of these substances were evaluated for antilipidemic ...