The preparation of 5-bromo-6-methoxy-8-aminoquinoline is described. It was found that this substance is transformed into its isomer, 6-methoxy-7-bromo-8-aminoquinoline, by means of boiling hydrobromic acid. This transformation gives evidence for the positive character of the bromine atom in the 5-position of 5-bromo-6-methoxy-8-aminoquinoline.