Designing nootropic dipeptides using an evolutionary-genetic approach

…, RU Ostrovskaya, TA Voronina, SB Seredenin

文献索引：Gudasheva; Trofimov; Morozova; Nikitin; Ostrovskaya; Voronina; Seredenin Pharmaceutical Chemistry Journal, 2006 , vol. 40, # 1 p. 18 - 22

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被引用次数: 1

摘要

Abstract A novel approach to the search for the new groups of biologically active peptides is developed, which is based on the selection of point mutants with respect to noncritical amino acid residues. Using a gene site encoding the arginine vasopressin AVP (4–5) sequence, which corresponds to the pGlu-Asn-NH 2 nootropic dipeptide, three point mutants with respect to Asn (pGlu-Ser-NH 2, pGlu-Asp-NH 2, and pGlu-His-NH 2) have been ...