Journal of medicinal chemistry

Pyridoquinoxaline N-oxides. 1. A new class of antitrichomonal agents

E Glazer, L Chappel

文献索引：Glazer, Edward A.; Chappel, Larry R. Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 766 - 769

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被引用次数: 15

摘要

An aspect of our work with quinoxaline 1, Cdioxides involved the synthesis and reactivity of (quinoxalin-2-y1) acrylonitrile 1, 4-dioxide. We have found that treatment of a methanolic solution of this unsaturated nitrile (cis or trans) with primary alkylamines affords a novel series of pyrido [2, 3-b] quinoxaline 5-oxides. These tricyclic pyridoquinoxalines represent a unique class of agents with oral activity against trichomoniasis.