Long-chain triazolyl acids as inhibitors of osteoclastogenesis

AJ Marshall, JM Lin, A Grey, IR Reid, J Cornish…

文献索引：Marshall, Andrew J.; Lin, Jian-Ming; Grey, Andrew; Reid, Ian R.; Cornish, Jillian; Denny, William A. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4112 - 4119

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被引用次数: 1

摘要

Saturated fatty acids (eg, palmitic acid) are known to moderately inhibit the development of osteoclasts in vitro. In pursuit of more effective inhibitors of osteoclastogenesis we explored two new classes of palmitic acid analogues containing either an ether or triazolyl group at various positions along the chain. The compounds were evaluated for their ability to inhibit the formation of osteoclasts in primary mouse bone marrow cultures. The oxyacids were ...