Journal of medicinal chemistry

Synthesis, base-catalyzed hydrolytic reactivity, and anticancer evaluation of O-aryl phosphorodiamidates as a novel class of pro (phosphorodiamidic acid mustards)

FT Chiu, FP Tsui, G Zon

文献索引：Chiu,F.-T. et al. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 802 - 807

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被引用次数: 6

摘要

Bis (2-chloroethyl) phosphoramidic dichloride [MP (O) Cl,, M= N (CH, CH, Cl),] has been used as the starting material for the synthesis of 0-aryl phosphorodiamidates having the general structure MP (O)(NHR) OAr: 9, R= H, Ar= 4-N02C6H4; 10, R= H, Ar= C6F5; 11, R= C6H5, Ar= C6F5; 12, R= 4-MeCsH4, Ar= CsF5; and 13, R= 4-EtOC6H4, Ar= C6F5. The phosphorodiamidic chloride precursor to 13 (14) was also isolated. Kinetics for the base- ...