Griseolic acid B 9, a recently discovered nucleoside, has been synthesised using a radical cyclisation as the key step in the formation of the unusual monosaccharide (Scheme 2). 26 The synthesis uses a cyclisation of a vinyl radical 6 onto an alkene. The use of vinyl radicals is surprisingly not common and can be expected to have much wider application. The intermediate vinyl radical, generated from a vinyl iodide precursor 5, undergoes the ...
