European journal of medicinal chemistry

Synthesis and receptor docking studies of N-substituted indole-2-carboxylic acid esters as a search for COX-2 selective enzyme inhibitors

S Olgen, E Akaho, D Nebioglu

文献索引：Olgen, Sureyya; Akaho, Eiichi; Nebioglu, Dogu European Journal of Medicinal Chemistry, 2001 , vol. 36, # 9 p. 747 - 770

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被引用次数: 39

摘要

A series of N-substituted indole-2-carboxylic acid esters have been prepared by replacing the benzoyl group of indomethacin with a benzyl and a phenyl group. The carbocyclic acid side chain was extended via creating an ester structure by using several dialkylaminoalkyl groups. The receptor docking studies were performed to investigate the docking mode of each compound by using dock 4.0. All the compounds were shown to be docked at the ...