Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates

…, S Hutter, G Casano, M Robin, C Pannecouque…

文献索引：Darque, Albert; Dumetre, Aurelien; Hutter, Sebastien; Casano, Gilles; Robin, Maxime; Pannecouque, Christophe; Azas, Nadine Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 20 p. 5962 - 5964

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被引用次数: 22

摘要

We have synthesized quinolinones with potential antiparasitic and anti-HIV activities by an original two-step method involving microwave irradiation and have evaluated their activities against Plasmodium falciparum, Leishmania donovani, Trichomonas vaginalis, and HIV. None of the tested compounds had been previously described using this method of synthesis. One of the compounds had interesting antiparasitic and anti-HIV activity, which ...