Design, synthesis and biological evaluation of 3-(4-halophenyl)-3-oxopropanal and their derivatives as novel antibacterial agents

…, W Yi, J Hu, F Wu, L Zhao, H Song, Z Wang

文献索引：Liu, Jinbing; Yi, Wei; Hu, Jianming; Wu, Fengyan; Zhao, Liangzhong; Song, Huacan; Wang, Zhihou Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 9 p. 1127 - 1131

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被引用次数: 3

摘要

In continuing our program aimed to search for potent drugs for bacterial infections, a series of 3-(4-halophenyl)-3-oxopropanal and their derivatives were designed, synthesized and their antibacterial activities in vitro against both Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa were evaluated. Compounds 7, 8, 13—16, 21 and 22 had moderate antibacterial activities ...