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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase

…, SP Canavan, PR Hirst, C Ramsey, AMW Stead…

文献索引：Boa, Andrew N.; Canavan, Shane P.; Hirst, Paul R.; Ramsey, Christopher; Stead, Andrew M.W.; McConkey, Glenn A. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1945 - 1967

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被引用次数: 60

摘要

A series of 2-phenyl quinoline-4-carboxylic acid derivatives related to brequinar, an inhibitor of human dihydroorotate dehydrogenase (DHODH), has been prepared and evaluated as inhibitors of DHODH from the malaria parasite Plasmodium falciparum. Brequinar was essentially inactive against PfDHODH (IC50 880μM) whereas several members of the series inhibited PfDHODH. Unexpectedly, replacement of the carboxylic acid required for ...

乙醇结构式

3-甲基-2-苯基-4-喹啉甲酰氯结构式

3-甲基-2-苯基-4-喹啉甲酰氯

~%

4-Quinolinecarboxylicacid, 3-methyl-2-phenyl-, ethyl ester结构式

4-Quinolinecarb...

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3-甲基-2-苯基-4-喹啉羧酸结构式

3-甲基-2-苯基-4-喹啉羧酸

~%

4-Quinolinecarboxylicacid, 3-methyl-2-phenyl-, ethyl ester结构式

4-Quinolinecarb...

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5-甲基靛红结构式

苯乙酮结构式

~92%

6-甲基-2-苯基喹啉-4-羧酸结构式

6-甲基-2-苯基喹啉-4-羧酸

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水合氯醛结构式

邻甲苯胺结构式

~58%

2-(羟基亚氨基)-N-(2-甲基苯基)乙酰胺结构式

2-(羟基亚氨基)-N-(2-...

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7-甲基靛红结构式

苯乙酮结构式

~80%

8-甲基-2-苯基喹啉-4-羧酸结构式

8-甲基-2-苯基喹啉-4-羧酸

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6-bromomethyl-2-phenylquinoline-4-carboxylic acid diisopropylamide结构式

6-bromomethyl-2...

~83%

6-formyl-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

6-formyl-2-phen...

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6-methyl-2-phenylquinoline-4-carboxylic acid diisopropylamide结构式

6-methyl-2-phen...

~%

6-formyl-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

6-formyl-2-phen...

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6-methyl-2-phenyl-quinoline-4-carbonyl chloride结构式

6-methyl-2-phen...

~%

6-formyl-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

6-formyl-2-phen...

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6-甲基-2-苯基喹啉-4-羧酸结构式

6-甲基-2-苯基喹啉-4-羧酸

~%

6-formyl-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

6-formyl-2-phen...

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苯乙酮结构式

~%

6-formyl-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

6-formyl-2-phen...

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3-bromomethyl-2-phenylquinoline-4-carboxylic acid diisopropylamide结构式

3-bromomethyl-2...

~94%

3-formyl-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

3-formyl-2-phen...

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N,N-diisopropyl-3-methyl-2-phenylquinoline-4-carboxamide结构式

N,N-diisopropyl...

~%

3-formyl-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

3-formyl-2-phen...

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3-甲基-2-苯基-4-喹啉羧酸结构式

3-甲基-2-苯基-4-喹啉羧酸

~%

3-formyl-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

3-formyl-2-phen...

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3-甲基-2-苯基-4-喹啉甲酰氯结构式

3-甲基-2-苯基-4-喹啉甲酰氯

~%

3-formyl-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

3-formyl-2-phen...

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2-(羟基亚氨基)-N-(2-甲基苯基)乙酰胺结构式

2-(羟基亚氨基)-N-(2-...

~66%

7-甲基靛红结构式

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乙醇结构式

6-methyl-2-phenyl-quinoline-4-carbonyl chloride结构式

6-methyl-2-phen...

~10%

Ethyl 6-methyl-2-phenyl-4-quinolinecarboxylate结构式

Ethyl 6-methyl-...

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苯乙酮结构式

~%

Ethyl 6-methyl-2-phenyl-4-quinolinecarboxylate结构式

Ethyl 6-methyl-...

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6-甲基-2-苯基喹啉-4-羧酸结构式

6-甲基-2-苯基喹啉-4-羧酸

~%

Ethyl 6-methyl-2-phenyl-4-quinolinecarboxylate结构式

Ethyl 6-methyl-...

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三甲基碘化亚砜结构式

三甲基碘化亚砜

3-formyl-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

3-formyl-2-phen...

~78%

3-(oxiran-2-yl)-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

3-(oxiran-2-yl)...

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N,N-diisopropyl-3-methyl-2-phenylquinoline-4-carboxamide结构式

N,N-diisopropyl...

~%

3-(oxiran-2-yl)-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

3-(oxiran-2-yl)...

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3-bromomethyl-2-phenylquinoline-4-carboxylic acid diisopropylamide结构式

3-bromomethyl-2...

~%

3-(oxiran-2-yl)-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

3-(oxiran-2-yl)...

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3-甲基-2-苯基-4-喹啉羧酸结构式

3-甲基-2-苯基-4-喹啉羧酸

~%

3-(oxiran-2-yl)-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

3-(oxiran-2-yl)...

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3-甲基-2-苯基-4-喹啉甲酰氯结构式

3-甲基-2-苯基-4-喹啉甲酰氯

~%

3-(oxiran-2-yl)-2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide结构式

3-(oxiran-2-yl)...

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