An activated phosphate for an efficient amide and peptide coupling reagent

T Yasuhara, Y Nagaoka, K Tomioka

文献索引：Yasuhara, Tomohisa; Nagaoka, Yasuo; Tomioka, Kiyoshi Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 17 p. 2901 - 2902

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被引用次数: 16

摘要

Formation of amide and peptide bonds through a coupling reaction of carboxylic acids with amines is a fundamental synthetic operation. Although some coupling reagents are commercially available, coupling reactions of bulky acids with bulky amines still prove to be challenging. Therefore, continuing efforts are being made to develop more efficient coupling reagents such as aminium salts, 1 phosphonium salts, 2 halouronium or ...