High enantioselectivity in reductions with a chiral polymethylene-bridged bis (NADH) model compound

M Seki, N Baba, J Oda, Y Inouye

文献索引：Seki, Masahiko; Baba, Naomichi; Oda, Jun'ichi; Inouye, Yuzo Journal of Organic Chemistry, 1983 , vol. 48, # 8 p. 1370 - 1373

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被引用次数: 34

摘要

The asymmetric reduction with the bis (NAH) reductants 8-13 was carried out in a mixture of dry acetonitrile h bis (NA+) 2: n. 4 5: n. 7 3: n. 5 6: n. 8 4: n= 6 7: n-9 8: n. 4 11: n. 7 9: 17.5 12: n= 8 10: n. 6 13: n. 9 and dry chloroform in the presence of equimolar amounts of anhydrous magnesium perchlorate and the substrate at room temperature or at 50" C for 17- 96 h in the dark. As can be seen from Table 11, the optical yields of the product mandelate ...