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Preparation of N-Substituted 1-(3', 4'-Dihydroxyphenyl)-2-aminoethanols

JR Corrigan, MJ Langermann…

文献索引:Corrigan; Langermann; Moore Journal of the American Chemical Society, 1949 , vol. 71, p. 530

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被引用次数: 10

摘要

Our investigations were prompted by an observation of Konzett4 that l-(@-hydroxyphenyl)-2- isopropylaminoethanol was more active as a broncholdilator than the N-methyl analog (Synephrine). Konzett4 also studied the broncholytic properties of several N-alkyl analogs of epinephrine and reported that 1-(3 ', 4 '-dihydroxyphenyl}-were isolated in crystalline form. In certain cases where the hydrochlorides resisted crystallization it was found necessary to ...