Our investigations were prompted by an observation of Konzett4 that l-(@-hydroxyphenyl)-2- isopropylaminoethanol was more active as a broncholdilator than the N-methyl analog (Synephrine). Konzett4 also studied the broncholytic properties of several N-alkyl analogs of epinephrine and reported that 1-(3 ', 4 '-dihydroxyphenyl}-were isolated in crystalline form. In certain cases where the hydrochlorides resisted crystallization it was found necessary to ...