A novel V IV O–pyrimidinone complex: synthesis, solution speciation and human serum protein binding

…, MMCA Castro, F Avecilla, L Palacio, M Maestro…

文献索引：Goncalves, Gisela; Tomaz, Isabel; Correia, Isabel; Veiros, Luis F.; Castro, M. Margarida C. A.; Avecilla, Fernando; Palacio, Lorena; Maestro, Miguel; Kiss, Tamas; Jakusch, Tamas; Garcia, M. Helena V.; Pessoa, Joao Costa Dalton Transactions, 2013 , vol. 42, # 33 p. 11841 - 11861

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被引用次数: 19

摘要

The pyrimidinones mhcpe, 2-methyl-3H-5-hydroxy-6-carboxy-4-pyrimidinone ethyl ester (mhcpe, 1), 2, 3-dimethyl-5-benzyloxy-6-carboxy-4-pyrimidinone ethyl ester (dbcpe, 2) and N-methyl-2, 3-dimethyl-5-hydroxy-6-carboxyamido-4-pyrimidinone (N-MeHOPY, 3), are synthesized and their structures determined by single crystal X-ray diffraction. The acid– base properties of 1 are studied by potentiometric and spectrophotometric methods, the ...