Intramolecular Stereoselective Protonation of Aldehyde??Derived Enolates

…, M Richter, MT Gieseler, M Kalesse

文献索引：Kena-diba, Anastasie; Noll, Claudia; Richter, Michael; Gieseler, Marc Timo; Kalesse, Markus Angewandte Chemie - International Edition, 2010 , vol. 49, # 45 p. 8367 - 8369

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被引用次数: 22

摘要

The stereoselective protonation of enolates derived from aldehydes remains a challenging transformation and only a limited number of examples for the enantioselective protonation are reported.[1] Nevertheless, it has the potential to significantly optimize total synthesis by avoiding extensive protecting and functional group manipulations or changes in oxidation states.[2] In the course of our synthetic endeavors towards the natural product angiolam [3] ...