Both stereoisomers of 4-aminomethylcyclohexariecarboxylic acid (AMCHA) were isolated as early as 1900.'Although the trans isomer has been described as effecting marked inhibition of the fibrinolytic enzyme system, detailed evidence for assigning this configuration to the more active isomer was lacking. 2 These configurations have now been confirmed by fusion, whereby only t, he less active p form produced a lactam. The structure of this lactam was ...
