Organic letters

Tetrapropylammonium Perruthenate Catalyzed Glycol Cleavage to Carboxylic (Di) Acids

AKC Schmidt, CBW Stark

文献索引：Schmidt, Andrea-Katharina C.; Stark, Christian B. W. Organic Letters, 2011 , vol. 13, # 21 p. 5788 - 5791

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被引用次数: 16

摘要

A new method to accomplish glycol cleavage to carboxylic (di) acids in one step using catalytic amounts of tetrapropylammonium perruthenate (TPAP) together with N- methylmorpholine N-Oxide (NMO) as the stoichiometric oxidant is presented. In addition to regenerating the active catalyst, the N-oxide stabilizes intermediary carbonyl hydrates and thereby shifts a crucial equilibrium. The mild oxidation protocol is applicable to a broad ...