Cycloaddition reactions of nitrones,[1] azides,[2] and related 1, 3-dipolar species [3] are recognized as powerful tools for the construction of compounds with great utility in organic synthesis, chemical biology, and materials science. The conceptual model that underpins our understanding of this broad class of reactions was first formalized by Huisgen in 1963.[4] This seminal contribution to organic chemistry provided chemists with a unified framework ...
