Sodium 1, 4??dihydroxy??9, 10??anthraquinone??2??sulphonate interacts with calf thymus DNA in a way that mimics anthracycline antibiotics: an electrochemical and …

PS Guin, S Das, PC Mandal

文献索引：Guin, Partha Sarathi; Das, Saurabh; Mandal Journal of Physical Organic Chemistry, 2010 , vol. 23, # 6 p. 477 - 482

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被引用次数: 29

摘要

Abstract The anthracycline drugs, adriamycin and daunorubicin, efficient in the treatment of various human cancers, form strong intercalation complexes with DNA. The therapeutic efficiency and toxic properties of the drugs are associated with electron transfer processes, which correlate well with the redox behaviour of the compounds. Sodium 1, 4-dihydroxy 9, 10-anthraquinone-2-sulphonate (sodium quinizarin-2-sulphonate, NaLH 2)(Na-Qz-2S) is ...