Highly Efficient Asymmetric Michael Addition of Aldehydes to Nitroalkenes Catalyzed by a Simple trans??4??Hydroxyprolylamide

…, S Vera, A Mielgo, E Gómez??Bengoa

文献索引：Palomo, Claudio; Vera, Silvia; Mielgo, Antonia; Gomez-Bengoa, Enrique Angewandte Chemie - International Edition, 2006 , vol. 45, # 36 p. 5984 - 5987

全文：HTML全文

被引用次数: 170

摘要

Methods based exclusively on organocatalysts have become of major significance in synthetic chemistry.[1] The Michael addition of carbonyl compounds to nitroalkenes [2] is a challenging benchmark for such a development owing to its potential for the construction of a CÀC bond with simultaneous generation of up to three adjacent stereogenic centers and because of the pivotal importance of the nitro group as a precursor to many functionalities. ...