Enzymatic resolution of racemic secondary cyclic allylic alcohols

…, A Grudniewska, A Chojnacka, A Białońska…

文献索引：Winska, Katarzyna; Grudniewska, Aleksandra; Chojnacka, Anna; Bialonska, Agata; Wawrzenczyk, Czeslaw Tetrahedron Asymmetry, 2010 , vol. 21, # 6 p. 670 - 678

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被引用次数: 17

摘要

The resolutions of five racemic cyclic alcohols: 6, 6-dimethylcyclohex-2-en-1-ol (±)-5, 4, 4- dimethylcyclohex-2-en-1-ol (±)-7, 5, 5-dimethylcyclohex-2-en-1-ol (±)-11 and isomeric trans- (±)-13 and cis-piperitols (±)-14 are presented. They were resolved by enzymatic esterification with vinyl esters or by enzymatic hydrolysis of their racemic esters in phosphate buffer. The following lipases were used as biocatalysts: Novozyme 435 (Candida ...