Tetrahedron letters

The [18 F] 2-fluoro-1, 3-thiazolyl moiety—an easily-accessible structural motif for prospective molecular imaging radiotracers

FG Siméon, MT Wendahl, VW Pike

文献索引：Simeon, Fabrice G.; Wendahl, Matthew T.; Pike, Victor W. Tetrahedron Letters, 2010 , vol. 51, # 46 p. 6034 - 6036

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被引用次数: 10

摘要

2-Fluoro-1, 3-thiazoles were rapidly and efficiently labeled with no-carrier-added fluorine-18 (t1/2= 109.7 min) by treatment of readily prepared 2-halo precursors with cyclotron-produced [18F] fluoride ion. The [18F] 2-fluoro-1, 3-thiazolyl moiety constitutes a new and easily- labeled structural motif for prospective molecular imaging radiotracers.