Conformationally constrained analogues of N′-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl) thiourea as TRPV1 antagonists

JO Lim, MK Jin, HC Ryu, DW Kang, J Lee…

文献索引：European Journal of Medicinal Chemistry, , vol. 44, # 1 p. 322 - 331

全文：HTML全文

被引用次数: 3

摘要

... European Journal of Medicinal Chemistry. ... a Laboratory of Medicinal Chemistry, Research Institute ... EtOAc:hexanes = 1:5). 1 H NMR (CDCl 3 ) δ 6.93 (t, 1H, J = 7.6 Hz, H-3), 6.50–6.54 (m, 2H, H-2 and H-4), 3.55 (br s, 2H, NH 2 ), 2.73 (t, 2H, J = 6.1 Hz, H-5), 2.45 (t, 2H, J = 6.1 Hz ...