Benzothiopyranoindazoles, a new class of chromophore modified anthracenedione anticancer agents. Synthesis and activity against murine leukemias

…, GD Kanter, DF Ortwine, SG Ross-Kesten…

文献索引：Hollis Showalter; Angelo; Berman; Kanter; Ortwine; Ross-Kesten; Sercel; Turner; Werbel; Worth; Elslager; Leopold; Shillis Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1527 - 1539

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被引用次数: 69

摘要

The synthesis of the benzothiopyranoindazoles (3), a new class of chromophore modified anthracenediones related to mitoxantrone (l), is described. In this structural class the quinone moiety, which is believed to be responsible for the cardiotoxicity of the anthracyclines, has been designed out. The synthesis of the benzothiopyranoindazoles was carried out by a multistep sequence from requisite l-chloro-4-nitro-9H-thioxanthen-9-one ...