Synthesis of L??histidine specifically labelled with stable isotopes
…, KD Witters, J Baart, PJE Verdegem…
文献索引：Cappon, J. J.; Witters, K. D.; Baart, J.; Verdegem, P. J. E.; Hoek, A. C.; et al. Recueil des Travaux Chimiques des Pays-Bas, 1994 , vol. 113, # 6 p. 318 - 328
Abstract (2′-13 C)-,(1′-15 N)-and (3′-15 N)-L-Histidine were prepared according to a synthetic scheme that allows the 13 C or 15 N labelling of all carbon and nitrogen positions or any combination of positions. A 1, 5-disubstituted imidazole ring was constructed via condensation of tosylmethyl isocyanide with 3-phenylpropenal and subsequent cycloaddition of benzylamine. The imidazole intermediate was converted into 1-benzyl-5-( ...
