Synthesis and antiprotozoal evaluation of benzothiazolopyrroloquinoxalinones, analogues of kuanoniamine A

…, N Walchshofer, H Fillion, B Fenet, ME Sarciron

文献索引：Tapia, Ricardo A.; Prieto, Yolanda; Pautet, Felix; Walchshofer, Nadia; Fillion, Houda; Fenet, Bernard; Sarciron, Marie-Elizabeth Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 16 p. 3407 - 3412

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被引用次数: 25

摘要

Boc-aminoethylindoloquinone 8, a key intermediate for the building of pentacyclic quinoneimines, analogues of kuanoniamine A, was synthesized by alkylation of 4, 7- dimethoxyindole 3 with 1, 2-dibromoethane followed by transformation into azide, reduction of the latter with trimethylphosphine in the presence of 2-(tert-butoxycarbonyloximino)-2- phenylacetonitrile and oxydative demethylation of the Boc-amine 6 with silver (II) oxide. ...