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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis of some phosphonates with antiherpetic activity

…, UJ Salvador, F Pancic, B Steinberg

文献索引：Diana, G. D.; Zalay, E. S.; Salvador, U. J.; Pancic, F.; Steinberg, B. Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 691 - 694

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被引用次数: 11

摘要

Several keto phosphonates, phosphonoacetates, and dialkyl phosphonates containing (ary1oxy) aryl groups were synthesized and evaluated for antiherpteic activity. Two of the most active compounds, 12 and 16, were evaluated topically in the mouse vaginal model against herpes simplex virus (HSV) type 2. Compound 16 exhibited an increased survival rate, as well as increased survival time. Evaluation of 16 in the guinea pig skin test against ...

[4-(6-diethoxyphosphorylhexoxy)phenyl] acetate结构式

[4-(6-diethoxyp...

~73%

4-(6-diethoxyphosphorylhexoxy)phenol结构式

4-(6-diethoxyph...

acetic acid,4-(2-bromoethoxy)phenol结构式

acetic acid,4-(...

~%

4-(6-diethoxyphosphorylhexoxy)phenol结构式

4-(6-diethoxyph...

乙酰基甲基膦酸二乙酯结构式

乙酰基甲基膦酸二乙酯

8-(2-chloro-4-methoxyphenoxy)octyl bromide结构式

8-(2-chloro-4-m...

~%

11-(2-chloro-4-methoxyphenoxy)-3-diethoxyphosphorylundecan-2-one结构式

11-(2-chloro-4-...

1-(6-bromohexoxy)-4-chlorobenzene结构式

1-(6-bromohexox...

亚磷酸三乙酯结构式

亚磷酸三乙酯

~64%

1-chloro-4-(6-diethoxyphosphorylhexoxy)benzene结构式

1-chloro-4-(6-d...

乙酰基甲基膦酸二乙酯结构式

乙酰基甲基膦酸二乙酯

1-((5-bromopentyl)oxy)-2-chloro-4-methoxybenzene结构式

1-((5-bromopent...

~%

8-(2-chloro-4-methoxyphenoxy)-3-diethoxyphosphoryloctan-2-one结构式

8-(2-chloro-4-m...

乙酰基甲基膦酸二乙酯结构式

乙酰基甲基膦酸二乙酯

2-chloro-1-(4-iodobutoxy)-4-methoxybenzene结构式

2-chloro-1-(4-i...

~%

7-(2-chloro-4-methoxyphenoxy)-3-diethoxyphosphorylheptan-2-one结构式

7-(2-chloro-4-m...

乙酰基甲基膦酸二乙酯结构式

乙酰基甲基膦酸二乙酯

4-[(6-bromohexyl)oxy]-3-chloroanisole结构式

4-[(6-bromohexy...

~%

9-(2-chloro-4-methoxyphenoxy)-3-diethoxyphosphorylnonan-2-one结构式

9-(2-chloro-4-m...

8-(2-chloro-4-methoxyphenoxy)octyl bromide结构式

8-(2-chloro-4-m...

亚磷酸三乙酯结构式

亚磷酸三乙酯

~33%

2-chloro-1-(8-diethoxyphosphoryloctoxy)-4-methoxybenzene结构式

2-chloro-1-(8-d...

7-(2-chloro-4-methoxyphenoxy)heptyl bromide结构式

7-(2-chloro-4-m...

亚磷酸三乙酯结构式

亚磷酸三乙酯

~38%

2-chloro-1-(7-diethoxyphosphorylheptoxy)-4-methoxybenzene结构式

2-chloro-1-(7-d...

6-(4-carbethoxyphenoxy)hexyl bromide结构式

6-(4-carbethoxy...

亚磷酸三乙酯结构式

亚磷酸三乙酯

~49%

ethyl 4-(6-diethoxyphosphorylhexoxy)benzoate结构式

ethyl 4-(6-diet...

4-[(6-bromohexyl)oxy]-3-chloroanisole结构式

4-[(6-bromohexy...

亚磷酸三乙酯结构式

亚磷酸三乙酯

~37%

磷利酯结构式

1-(4-bromobutoxy)-2-chloro-4-methoxybenzene结构式

1-(4-bromobutox...

亚磷酸三乙酯结构式

亚磷酸三乙酯

~73%

2-chloro-1-(4-diethoxyphosphorylbutoxy)-4-methoxybenzene结构式

2-chloro-1-(4-d...

1-(3-bromopropoxy)-2-chloro-4-methoxybenzene结构式

1-(3-bromopropo...

亚磷酸三乙酯结构式

亚磷酸三乙酯

~65%

2-chloro-1-(3-diethoxyphosphorylpropoxy)-4-methoxybenzene结构式

2-chloro-1-(3-d...

亚磷酸三丙酯结构式

亚磷酸三丙酯

4-[(6-bromohexyl)oxy]-3-chloroanisole结构式

4-[(6-bromohexy...

~69%

2-chloro-1-(6-dipropoxyphosphorylhexoxy)-4-methoxybenzene结构式

2-chloro-1-(6-d...

6-(2,6-dichlorophenoxy)hexyl bromide结构式

6-(2,6-dichloro...

亚磷酸三乙酯结构式

亚磷酸三乙酯

~32%

1,3-dichloro-2-(6-diethoxyphosphorylhexoxy)benzene结构式

1,3-dichloro-2-...

1-((5-bromopentyl)oxy)-2-chloro-4-methoxybenzene结构式

1-((5-bromopent...

亚磷酸三乙酯结构式

亚磷酸三乙酯

~32%

2-chloro-1-(5-diethoxyphosphorylpentoxy)-4-methoxybenzene结构式

2-chloro-1-(5-d...

乙酰基甲基膦酸二乙酯结构式

乙酰基甲基膦酸二乙酯

7-(2-chloro-4-methoxyphenoxy)heptyl bromide结构式

7-(2-chloro-4-m...

~%

10-(2-chloro-4-methoxyphenoxy)-3-diethoxyphosphoryldecan-2-one结构式

10-(2-chloro-4-...

1-bromo-4-(6-bromohexyloxy)benzene结构式

1-bromo-4-(6-br...

亚磷酸三乙酯结构式

亚磷酸三乙酯

~43%

1-bromo-4-(6-diethoxyphosphorylhexoxy)benzene结构式

1-bromo-4-(6-di...