Enzymelike catalysis of the Nazarov cyclization by supramolecular encapsulation

…, MD Pluth, RG Bergman, KN Raymond

文献索引：Hastings, Courtney J.; Pluth, Michael D.; Bergman, Robert G.; Raymond, Kenneth N. Journal of the American Chemical Society, 2010 , vol. 132, # 20 p. 6938 - 6940

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被引用次数: 162

摘要

The water-soluble, self-assembled, tetrahedral assembly K12Ga4L6 (L= 1, 5- biscatecholamidenaphthalene) catalyzes the Nazarov cyclization of 1, 3-pentadienols with extremely high levels of efficiency. The catalyzed reaction proceeds over a million times faster than the background reaction, an increase comparable to those observed in some enzymatic systems. This catalysis operates under aqueous conditions at mild ...