Synthesis

Convenient Preparation of Halo-1, 3-thiazoles: Important Building Blocks for Materials and Pharmaceutical Synthesis

AM Grubb, MJ Schmidt, AJ Seed, P Sampson

文献索引：Grubb, Alan M.; Schmidt, Michael J.; Seed, Alexander J.; Sampson, Paul Synthesis, 2012 , vol. 44, # 7 p. 1026 - 1029

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被引用次数: 5

摘要

Abstract Convenient, scalable and high-yielding approaches to 2, 5-and 2, 4-dibromo-1, 3- thiazole are reported that offer significant improvements over previously reported approaches. 2, 5-Dibromo-1, 3-thiazole was generated in two steps from commercially inexpensive 2-amino-1, 3-thiazole, whereas 2, 4-dibromo-1, 3-thiazole was generated in a single step from commercially inexpensive 1, 3-thiazolidine-2, 4-dione. As part of this ...