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False positives in a reporter gene assay: identification and synthesis of substituted N-pyridin-2-ylbenzamides as competitive inhibitors of firefly luciferase

LH Heitman, JPD van Veldhoven…

文献索引:Journal of Medicinal Chemistry, , vol. 51, # 15 p. 4724 - 4729

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被引用次数: 33

摘要

... Journal of Medicinal ... Division of Medicinal Chemistry, Leiden/Amsterdam ... Chemistry The initial active compound, N-quinolin-2-ylbenzamide (1), was obtained from the reaction of 2-aminoquinoline with benzoyl chloride in pyridine.(14) On the basis of the interesting behavior ...