Gold-catalyzed reactions of 2-alkynyl-phenylamines with α, β-enones

…, A Arcadi, M Aschi, G Bianchi, F Marinelli

文献索引：Alfonsi, Maria; Arcadi, Antonio; Aschi, Massimiliano; Bianchi, Gabriele; Marinelli, Fabio Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2265 - 2273

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被引用次数: 158

摘要

The gold-catalyzed reaction of 2-alkynyl-phenylamines with α, β-enones represents a new general one-pot entry into C-3-alkyl-indoles by sequential reactions. Gold-catalyzed sequential cyclization/alkylation, N-alkylation/cyclization, or N-alkylation/cyclization/ alkylation reactions leading to different indoles can be directed by changing the 2-alkynyl- phenylamine 1/α, β-enone 3 ratio and the reaction temperature. Unusual gold-catalyzed ...