Novel sulfamides as potential carbonic anhydrase isoenzymes inhibitors

…, H Göçer, S Göksu, İ Gülçin, CT Supuran

文献索引：Akincioglu, Akin; Akbaba, Yusuf; Goecer, Huelya; Goeksu, Sueleyman; Guelcin, Ilhami; Supuran, Claudiu T. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 6 p. 1379 - 1385

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被引用次数: 58

摘要

Sulfamides represent an important class of biologically active compounds. A series of novel sulfamides were synthesized from 1-aminoindanes, 1-aminotetralin, 2-aminoindanes and 2- aminotetralin via the reactions of free amines, benzyl alcohol and chlorosulfonyl isocyanate (CSI) followed by hydrogenolysis of the obtained sulfamoylcarbamates. Carbonic anhydrase (CA, EC 4.2. 1.1) inhibitory effects of the new sulfamides have been investigated. The ...