Synthesis and evaluation of novel 18F-labeled spirocyclic piperidine derivatives as σ1 receptor ligands for positron emission tomography imaging

Y Li, X Wang, J Zhang, W Deuther-Conrad…

文献索引：Maisonial, Aurelie; Grosse Maestrup, Eva; Wiese, Christian; Hiller, Achim; Schepmann, Dirk; Fischer, Steffen; Deuther-Conrad, Winnie; Steinbach, Joerg; Brust, Peter; Wuensch, Bernhard Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 1 p. 257 - 269

全文：HTML全文

被引用次数: 11

摘要

A series of spirocyclic piperidine derivatives were designed and synthesized as σ1 receptor ligands. In vitro competition binding assays showed that 1′-(4-(2-fluoroethoxy) benzyl)-3 H- spiro [2-benzofuran-1, 4′-piperidine](19) possessed high σ1 receptor affinity (K i= 0.79 nM)