Synthesis and antitumor activity of 4-and 5-substituted derivatives of isoquinoline-1-carboxaldehyde thiosemicarbazone

…, TS Lin, P Penketh, AC Sartorelli

文献索引：Liu, Mao-Chin; Lin, Tai-Shun; Penketh, Philip; Sartorelli, Alan C. Journal of Medicinal Chemistry, 1995 , vol. 38, # 21 p. 4234 - 4243

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被引用次数: 54

摘要

Various substituted isoquinoline-1-carboxaldehyde thiosemicarbazones (12 compounds) have been synthesized and evaluated for antineoplastic activity in mice bearing the L1210 leukemia. Condensation of 4-bromo-1-methylisoquinoline (4) with ammonium hydroxide, methylamine, ethylamine, and N-acetylethylenediamine gave the corresponding 4-amino, 4- methylamino, 4-ethylamino, and 4-N-(acetylethyl) amino derivatives, which were then ...