Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents

L Briseno-Roa, J Hill, S Notman, D Sellers…

文献索引：Journal of Medicinal Chemistry, , vol. 49, # 1 p. 246 - 255

全文：HTML全文

被引用次数: 68

摘要

... Journal of Medicinal Chemistry. ... b The 'catalytic efficiencies' of BuChE are k cat /K d values. c ND = not determined. It could also be attractive to use enzymes which hydrolyze NAs for medical treatment of individuals exposed, or at risk of exposure, to CW agents. ...