Abstract Itanoxone synthesis by Friedel-Crafts reaction between itaconic anhydride and 2- chlorobiphenyl was studied. Five isomers corresponding to possible impurities were prepared and studied to perfect a reliable and practical method to detect these impurities in itanoxone.
![2-[2-(4'-CHLORO-BIPHENYL-4-YL)-2-OXO-ETHYL]ACRYLIC ACID结构式](https://image.chemsrc.com/caspic/087/58211-82-8.png)